In the early minutes of the second half, Besiktas winger Gokhan Tore scored the first goal for Besiktas, 1-0. Home team Club Brugge equalized the level when De Sutter flicked the ball into the net in the 62nd minute, 1-1.
Club Brugge came back when Israeli winger Lior Refaelov scored from the penalty kick in the 79th minute, 2-1.
Belgians now have the advantage in the second leg of the tournament that kicks off on March 19 in Istanbul.
Zenit 2-0 Torino
Wolfsburg 3-1 Inter
Club Brugge 2-1 Besiktas
Dnipro 1-0 Ajax